Shift Molecular III (electroporation for transfer of the active drug) is the greatest innovation in technology and therapeutic area, due to their construction and operation, which stand out significantly compared to any other system on the market . The goal of the Molecular Shift III (molecular transfer) is to optimize the transdermal transport of active substances in the tissues of the body, with complete safety for  patient and the person usually presented to them. The benefits of the administration of medicines with this mode are essentially: 

• Avoid systemic administration (oral, intramuscular, intravenous)

• Apply the medication directly into the body when affected by disease;

• Allow the introduction of the only active ingredient, with no carrier (excipients)

• Allowing ions to bind to certain proteins protoplasmic;

• Hyperpolarized the nerve endings.

BIOLOGICAL EFFECTS

• Anti-inflammatory therapeutics

• Pain Therapy

• The oxygenation of damaged tissues

• Cellular bio stimulation

• Transdermal delivery of active ingredients

CONCLUSIONS:  This method is completely non-invasive, because it eliminates the use of needles, also called "virtual syringe’ or injection without needle , with great relief by patients, because there is no traumatic effect. Treatment of pain: This technique combating inflammation and therefore pain and allows the transfer of molecules of the active ingredients deep into the tissue (from 0.5 cm to 10 cm).

Today there is much debate about the potential for dermal absorption and permeability of different molecules, whereas the main difficulties in the release and penetration through the human body are the outer layer of skin (dermis). That is different from layers of cells and is presented as a "shield" that prevents the entry of any harmful substance in the body.  The history through which we come to build the shift Molecular III, which can create almost the physical phenomenon called "Electroporation" takes into account previous studies of physical phenomena, produced by other methods, such as:  

- IONOPHORESIS = creates the ionization of a substance using a continuous form of electricity (galvanic).

 - IONTOPHORESIS, creates the ionization of a substance with the aid of electric current in the form of waves pulsate. The limitations of these techniques, however, are the following:

1) Low quantity of active substances that can be transferred to the deep tissues.

2) The limited penetration depth in tissue

3) High concentration of the active ingredient in a small area and not as desired.  The electroporation system is a transdermal delivery system, which overcomes the limitations of the techniques used earlier in the administration of medical treatment for different drugs in orthopedics, rheumatology, dermatology and aesthetics.  When an electrical pulse hits a cell, generating a transmembrane potential and consequently the lipid layer of the cell membrane changes and gives order 'in the formation of "watery canals’, also called electroporation. These channels remain open for a period of time ranging generally from a few seconds to a few tens of minutes.  That’s consequently' a phenomenon of cell membrane very important for the advancement of biology, biotechnology and medicine, which allows the penetration of active ingredients water soluble high molecular weight, up to 90%, for example, hyaluronic acid, collagen, vitamin C, and the 'esapeptide. Molecular Device Shift III (molecular transfer) consists of a handful that provides both a 'light electricity ‘and a blue laser beam for the electroporation of the molecules.

By then the opening of electro pores on the skin, the substances pass through osmosis from one cell to another one and are released in the deep compartment of the skin. For the penetration of the active substances of the medicines by using a conductive gel.

The benefits of administration of medicines with this mode are essentially:

• Avoid systemic administration (oral, intramuscular, intravenous)

• Apply the medication directly into the body when affected by disease;

• Allow the introduction of the only active ingredient, with no carrier (excipients)

• Allowing ions to bind to certain proteins protoplasmic;

• Hyperpolarized the nerve endings.

Effects:

• Anti-inflammatory therapeutics

• Pain Therapy

• The oxygenation of damaged tissues

• Cellular bio stimulation

• Transdermal delivery of active ingredients

CONCLUSIONS:  This method is completely non-invasive, because it eliminates the use of needles, also called "virtual syringe’ or injection without needle , with great relief by patients, because there is no traumatic effect.  Treatment of pain:  This technique combating inflammation and therefore pain and allows the transfer of molecules of the active ingredients deep into the tissue (from 0.5 cm to 10 cm).

INDICATIONS Fast very encouraging results obtained in the treatment of 'acute and chronic inflammation in Osseo articular disorders, neuromuscular diseases, degenerative joint diseases, in particular, tendinitis, carpal tunnel syndrome, epicondylitis , muscle trauma, and the elimination of edema. Shift Molecular III gives very good results in neurological disorders, in orthopedic disorders, sports medicine, and Rheumatology

The duration of treatment varies from 15 to 30 minutes depending on the amount of the drug substance to be penetrated.

Contraindications of Shift Molecular III

The treatment is contraindicated in individuals with:

• pacemaker

• Tuberculosis

• Malignancies

• fever and infections

• Severe renal impairment

• Thrombusphlebitis

• Psychiatric disorders and / or psychosomatic disorders

• Nodules

• Presence of metallic implants Consult your doctor if:

• Pregnancy

• Hypertension

• Hypotension

• Phlebitis

• Asthma.

Treatment with the shift Molecular III can be 'combined with ATR Med Tecar getting outstanding achievement in physical therapy for various orthopedic disorders, neurological, rheumatologic, sport medicine and also in aesthetics.